Mistriotis Lab - Publications

3D confinement alters smooth muscle cell responses to chemical and mechanical cues

Farnaz Hemmati, Ayuba Akinpelu, Daniel Chinedu Nweze, Panagiotis Mistriotis

APL Bioengineering · 25 Oct 2024

Differential effects of confinement‐induced reactive oxygen species accumulation on highly motile cancerous and non‐cancerous cells

William Collins Keith, Farnaz Hemmati, Ravi Sureshbhai Vaghasiya, Farshad Amiri, Panagiotis Mistriotis

AIChE Journal · 04 Sep 2024

reactive oxygen species confined migration fibrosarcoma cells human dermal fibroblasts

Confinement controls the directional cell responses to fluid forces

Farshad Amiri, Ayuba A. Akinpelu, William C. Keith, Farnaz Hemmati, Ravi S. Vaghasiya, Dylan Bowen, Razan S. Waliagha, Chuanyu Wang, Pengyu Chen, Amit K. Mitra, Yizeng Li, Panagiotis Mistriotis

Cell Reports · 01 Sep 2024

upstream cell migration tight confinement chemotaxis metastatic tumor cells

Leveraging Cell Migration Dynamics to Discriminate Between Senescent and Presenescent Human Mesenchymal Stem Cells

Farshad Amiri, Panagiotis Mistriotis

Cellular and Molecular Bioengineering · 20 Jul 2024

cell migration human mesenchymal stem cells senescent stem cells presenescent stem cells

Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics

Tosin Akinsipe, Rania Mohamedelhassan, Ayuba Akinpelu, Satyanarayana R. Pondugula, Panagiotis Mistriotis, L. Adriana Avila, Amol Suryawanshi

Frontiers in Immunology · 12 Mar 2024

breast cancer tumor progression tumor microenvironment metastasis

The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression

Ayuba Akinpelu, Tosin Akinsipe, L. Adriana Avila, Robert D. Arnold, Panagiotis Mistriotis

Cancer and Metastasis Reviews · 19 Jan 2024

metastasis breast cancer physical stimuli cell migration

Coordinated in confined migration: crosstalk between the nucleus and ion channel-mediated mechanosensation

Panagiotis Mistriotis, Emily O. Wisniewski, Bishwa R. Si, Petr Kalab, Konstantinos Konstantopoulos

Trends in Cell Biology · 01 Jan 2024

cell nucleus confinement cell migration mechanosensation

Metronomic Administration of Topotecan Alone and in Combination with Docetaxel Inhibits Epithelial–mesenchymal Transition in Aggressive Variant Prostate Cancers

Taraswi Mitra Ghosh, Suman Mazumder, Joshua Davis, Jyoti Yadav, Ayuba Akinpelu, Ahmed Alnaim, Harish Kumar, Razan Waliagha, Allison E. Church Bird, Soroush Rais-Bahrami, R. Curtis Bird, Panagiotis Mistriotis, Amarjit Mishra, Clayton C. Yates, Amit K. Mitra, Robert D. Arnold

Cancer Research Communications · 19 Jul 2023

prostate cancer chemotherapy topotecan docetaxel

Downregulation of YAP Activity Restricts P53 Hyperactivation to Promote Cell Survival in Confinement

Farnaz Hemmati, Ayuba Akinpelu, Jiyeon Song, Farshad Amiri, Anya McDaniel, Collins McMurray, Alexandros Afthinos, Stelios T. Andreadis, Andrew V. Aitken, Vinicia C. Biancardi, Sharon Gerecht, Panagiotis Mistriotis

Advanced Science · 02 Jun 2023

cell migration YAP activity confinement P53 activation

Cytokinesis machinery promotes cell dissociation from collectively migrating strands in confinement

Robert A. Law, Alexander Kiepas, Habben E. Desta, Emiliano Perez Ipiña, Maria Parlani, Se Jong Lee, Christopher L. Yankaskas, Runchen Zhao, Panagiotis Mistriotis, Nianchao Wang, Zhizhan Gu, Petr Kalab, Peter Friedl, Brian A. Camley, Konstantinos Konstantopoulos

Science Advances · 13 Jan 2023

cytokinesis cell dissemination confinement

Integrating Pharmacogenomics Data-Driven Computational Drug Prediction with Single-Cell RNAseq to Demonstrate the Efficacy of a NAMPT Inhibitor against Aggressive, Taxane-Resistant, and Stem-like Cells in Lethal Prostate Cancer

Suman Mazumder, Taraswi Mitra Ghosh, Ujjal K. Mukherjee, Sayak Chakravarti, Farshad Amiri, Razan S. Waliagha, Farnaz Hemmati, Panagiotis Mistriotis, Salsabil Ahmed, Isra Elhussin, Ahmad-Bin Salam, Windy Dean-Colomb, Clayton Yates, Robert D. Arnold, Amit K. Mitra

Cancers · 06 Dec 2022

single-cell RNAseq pharmacogenomics prostate cancer

Extracellular fluid viscosity enhances cell migration and cancer dissemination

Kaustav Bera, Alexander Kiepas, Inês Godet, Yizeng Li, Pranav Mehta, Brent Ifemembi, Colin D. Paul, Anindya Sen, Selma A. Serra, Konstantin Stoletov, Jiaxiang Tao, Gabriel Shatkin, Se Jong Lee, Yuqi Zhang, Adrianna Boen, Panagiotis Mistriotis, Daniele M. Gilkes, John D. Lewis, Chen-Ming Fan, Andrew P. Feinberg, Miguel A. Valverde, Sean X. Sun, Konstantinos Konstantopoulos

Nature · 02 Nov 2022

cell migration extracellular fluid viscosity cancer metastasis

Source

Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis

Yuqi Zhang, Yizeng Li, Keyata N. Thompson, Konstantin Stoletov, Qinling Yuan, Kaustav Bera, Se Jong Lee, Runchen Zhao, Alexander Kiepas, Yao Wang, Panagiotis Mistriotis, Selma A. Serra, John D. Lewis, Miguel A. Valverde, Stuart S. Martin, Sean X. Sun, Konstantinos Konstantopoulos

Nature Communications · 17 Oct 2022

cell migration metastasis SWELL1 polarized NHE1

Source

Migration and 3D Traction Force Measurements inside Compliant Microchannels

Alexandros Afthinos, Kaustav Bera, Junjie Chen, Altug Ozcelikkale, Alice Amitrano, Mohammad Ikbal Choudhury, Randy Huang, Pavlos Pachidis, Panagiotis Mistriotis, Yun Chen, Konstantinos Konstantopoulos

Nano Letters · 15 Sep 2022

cell migration stiffness 3D traction force

Integrating pharmacogenomics data-driven prediction with bulk and single-cell RNAseq to demonstrate the efficacy of an NAMPT inhibitor against aggressive, taxane-resistant, and stem-like cells in lethal prostate cancer

Suman Mazumder, Taraswi Mitra Ghosh, Ujjal K. Mukherjee, Sayak Chakravarti, Farshad Amiri, Farnaz Hemmati, Panagiotis Mistriotis, Isra Elhussin, Ahmad-bin Salam, Windy Dean-Colomb, Feng Li, Clayton Yates, Robert D. Arnold, Amit K. Mitra

Cold Spring Harbor Laboratory · 22 Jul 2022

pharmacogenomics single-cell RNAseq NAMPT inhibitor prostate cancer

Kidney epithelial cells are active mechano-biological fluid pumps

Mohammad Ikbal Choudhury, Yizeng Li, Panagiotis Mistriotis, Ana Carina N. Vasconcelos, Eryn E. Dixon, Jing Yang, Morgan Benson, Debonil Maity, Rebecca Walker, Leigha Martin, Fatima Koroma, Feng Qian, Konstantinos Konstantopoulos, Owen M. Woodward, Sean X. Sun

Nature Communications · 28 Apr 2022

kidney morphogenesis tissues

The fluid shear stress sensor TRPM7 regulates tumor cell intravasation

Christopher L. Yankaskas, Kaustav Bera, Konstantin Stoletov, Selma A. Serra, Julia Carrillo-Garcia, Soontorn Tuntithavornwat, Panagiotis Mistriotis, John D. Lewis, Miguel A. Valverde, Konstantinos Konstantopoulos

Science Advances · 09 Jul 2021

fluid shear stress TRPM7 intravasation

Abstract 1354: Deciphering the functional basis of synergy between taxanes and TAK715: A novel repurposed drug candidate in treatment-refractory aggressive prostate cancer

Sayak Chakravarti, Suman Mazumder, Farnaz Hemmati, Farshad Amiri, Taraswi Mitra Ghosh, Ujjal Kumar Mukherjee, Panagiotis Mistriotis, Timothy Moore, Robert Arnold, Clayton Yates, Amit Kumar Mitra

Cancer Research · 01 Jul 2021

taxanes TAK715 prostate cancer

A Procarcinogenic Colon Microbe Promotes Breast Tumorigenesis and Metastatic Progression and Concomitantly Activates Notch and β-Catenin Axes

Sheetal Parida, Shaoguang Wu, Sumit Siddharth, Guannan Wang, Nethaji Muniraj, Arumugam Nagalingam, Christina Hum, Panagiotis Mistriotis, Haiping Hao, C. Conover Talbot, Konstantinos Konstantopoulos, Kathleen L. Gabrielson, Cynthia L. Sears, Dipali Sharma

Cancer Discovery · 06 Jan 2021

procarcinogenic microbe breast tumorigenesis metastasis

Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma

Rajappa S. Kenchappa, Panagiotis Mistriotis, Emily Wisniewski, Santanu Bhattacharya, Tanmay Kulkarni, Rita West, Amanda Luu, Meghan Conlon, Ernest Heimsath, James F. Crish, Hannah S. Picariello, Athanassios Dovas, Natanael Zarco, Montserrat Lara-Velazquez, Alfredo Quiñones-Hinojosa, John A. Hammer, Debrabrata Mukhopadhyay, Richard E. Cheney, Konstantinos Konstantopoulos, Peter Canoll, Steven S. Rosenfeld

iScience · 01 Dec 2020

myosin 10 glioblastoma metabolic signaling

Dorsoventral polarity directs cell responses to migration track geometries

Emily O. Wisniewski, Panagiotis Mistriotis, Kaustav Bera, Robert A. Law, Jitao Zhang, Milos Nikolic, Michael Weiger, Maria Parlani, Soontorn Tuntithavornwat, Alexandros Afthinos, Runchen Zhao, Denis Wirtz, Petr Kalab, Giuliano Scarcelli, Peter Friedl, Konstantinos Konstantopoulos

Science Advances · 31 Jul 2020

dorsoventral polarity cell migration

Abstract PR06: Bacteroides fragilis: A potential pathogen orchestrating EMT and stemness in breast epithelial cells via concomitant activation of Notch and βcatenin axes

Sheetal Parida, Shaoguang Wu, Nethaji Muniraj, Sumit Siddharth, Arumugam Nagaligam, Christina Hum, Panagiotis Mistriotis, Konstantinos Konstantopoulos, Cynthia Sears, Dipali Sharma

Cancer Research · 15 Apr 2020

breast epithelial cells Bacteroides fragilis

Confinement hinders motility by inducing RhoA-mediated nuclear influx, volume expansion, and blebbing

Panagiotis Mistriotis, Emily O. Wisniewski, Kaustav Bera, Jeremy Keys, Yizeng Li, Soontorn Tuntithavornwat, Robert A. Law, Nicolas A. Perez-Gonzalez, Eda Erdogmus, Yuqi Zhang, Runchen Zhao, Sean X. Sun, Petr Kalab, Jan Lammerding, Konstantinos Konstantopoulos

Journal of Cell Biology · 05 Nov 2019

nuclear influx confinement RhoA motility

Restoring extracellular matrix synthesis in senescent stem cells

Na Rong, Panagiotis Mistriotis, Xiaoyan Wang, Georgios Tseropoulos, Nika Rajabian, Yali Zhang, Jianmin Wang, Song Liu, Stelios T. Andreadis

The FASEB Journal · 09 Jul 2019

extracellular matrix senescent stem cells

Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area

Runchen Zhao, Alexandros Afthinos, Tian Zhu, Panagiotis Mistriotis, Yizeng Li, Selma A. Serra, Yuqi Zhang, Christopher L. Yankaskas, Shuyu He, Miguel A. Valverde, Sean X. Sun, Konstantinos Konstantopoulos

Science Advances · 05 Jul 2019

TRPM7 confinement hydraulic pressure

A Direct Podocalyxin–Dynamin-2 Interaction Regulates Cytoskeletal Dynamics to Promote Migration and Metastasis in Pancreatic Cancer Cells

Bin Sheng Wong, Daniel J. Shea, Panagiotis Mistriotis, Soontorn Tuntithavornwat, Robert A. Law, Jake M. Bieber, Lei Zheng, Konstantinos Konstantopoulos

Cancer Research · 01 Jun 2019

pancreatic cancer cells migration metastasis

A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens

Christopher L. Yankaskas, Keyata N. Thompson, Colin D. Paul, Michele I. Vitolo, Panagiotis Mistriotis, Ankit Mahendra, Vivek K. Bajpai, Daniel J. Shea, Kristen M. Manto, Andreas C. Chai, Navin Varadarajan, Aikaterini Kontrogianni-Konstantopoulos, Stuart S. Martin, Konstantinos Konstantopoulos

Nature Biomedical Engineering · 06 May 2019

microfluidic assay breast cancer metastasis

Exposing Cell-Itary Confinement: Understanding the Mechanisms of Confined Single Cell Migration

Bin Sheng Wong, Panagiotis Mistriotis, Konstantinos Konstantopoulos

Advances in Experimental Medicine and Biology · 01 Jan 2018

osmotic engine cell blebbing amoeboid migration confinement

Vascular aging: Molecular mechanisms and potential treatments for vascular rejuvenation

Panagiotis Mistriotis, Stelios T. Andreadis

Ageing Research Reviews · 01 Aug 2017

vscular aging vascular rejuvenation

Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3

S Sengupta, A Nagalingam, N Muniraj, M Y Bonner, P Mistriotis, A Afthinos, P Kuppusamy, D Lanoue, S Cho, P Korangath, M Shriver, A Begum, V F Merino, C-Y Huang, J L Arbiser, W Matsui, B Győrffy, K Konstantopoulos, S Sukumar, P A Marignani, N K Saxena, D Sharma

Oncogene · 05 Jun 2017

LKB1 breast cancer Stat3 inhibition

NANOG Restores Contractility of Mesenchymal Stem Cell-Based Senescent Microtissues

Aref Shahini, Panagiotis Mistriotis, Mohammadnabi Asmani, Ruogang Zhao, Stelios T. Andreadis

Tissue Engineering Part A · 01 Jun 2017

nanog contractility mesenchymal stem cells

Cancer cell motility: lessons from migration in confined spaces

Colin D. Paul, Panagiotis Mistriotis, Konstantinos Konstantopoulos

Nature Reviews Cancer · 02 Dec 2016

cell motility migation cancer confined spaces

NANOG Reverses the Myogenic Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression

Panagiotis Mistriotis, Vivek K. Bajpai, Xiaoyan Wang, Na Rong, Aref Shahini, Mohammadnabi Asmani, Mao-Shih Liang, Jianmin Wang, Pedro Lei, Song Liu, Ruogang Zhao, Stelios T. Andreadis

Stem Cells · 11 Jul 2016

nanog myogenic differentiation senescent stem cells

Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation

Roshan M Padmashali, Panagiotis Mistriotis, Mao-shih Liang, Stelios T Andreadis

Molecular Therapy · 01 Nov 2014

lentiviral arrays differentiation dynamic monitoring

Poly(ethylene glycol)-block-cationic polylactide nanocomplexes of differing charge density for gene delivery

Chih-Kuang Chen, Charles H. Jones, Panagiotis Mistriotis, Yun Yu, Xiaoni Ma, Anitha Ravikrishnan, Ming Jiang, Stelios T. Andreadis, Blaine A. Pfeifer, Chong Cheng

Biomaterials · 01 Dec 2013

cationic polymer nanocomplex gene delivery