Mistriotis Lab

Publications

2023

Cytokinesis machinery promotes cell dissociation from collectively migrating strands in confinement
Robert A. Law, Alexander Kiepas, Habben E. Desta, Emiliano Perez Ipiña, Maria Parlani, Se Jong Lee, Christopher L. Yankaskas, Runchen Zhao, Panagiotis Mistriotis, Nianchao Wang, Zhizhan Gu, Petr Kalab, Peter Friedl, Brian A. Camley, Konstantinos Konstantopoulos
Science Advances  ·  13 Jan 2023
cytokinesiscell disseminationconfinement

2022

Integrating Pharmacogenomics Data-Driven Computational Drug Prediction with Single-Cell RNAseq to Demonstrate the Efficacy of a NAMPT Inhibitor against Aggressive, Taxane-Resistant, and Stem-like Cells in Lethal Prostate Cancer
Suman Mazumder, Taraswi Mitra Ghosh, Ujjal K. Mukherjee, Sayak Chakravarti, Farshad Amiri, Razan S. Waliagha, Farnaz Hemmati, Panagiotis Mistriotis, Salsabil Ahmed, Isra Elhussin, Ahmad-Bin Salam, Windy Dean-Colomb, Clayton Yates, Robert D. Arnold, Amit K. Mitra
Cancers  ·  06 Dec 2022
single-cell RNAseqpharmacogenomicsprostate cancer
Extracellular fluid viscosity enhances cell migration and cancer dissemination
Kaustav Bera, Alexander Kiepas, Inês Godet, Yizeng Li, Pranav Mehta, Brent Ifemembi, Colin D. Paul, Anindya Sen, Selma A. Serra, Konstantin Stoletov, Jiaxiang Tao, Gabriel Shatkin, Se Jong Lee, Yuqi Zhang, Adrianna Boen, Panagiotis Mistriotis, Daniele M. Gilkes, John D. Lewis, Chen-Ming Fan, Andrew P. Feinberg, Miguel A. Valverde, Sean X. Sun, Konstantinos Konstantopoulos
Nature  ·  02 Nov 2022
cell migrationextracellular fluid viscositycancer metastasis
Source
Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis
Yuqi Zhang, Yizeng Li, Keyata N. Thompson, Konstantin Stoletov, Qinling Yuan, Kaustav Bera, Se Jong Lee, Runchen Zhao, Alexander Kiepas, Yao Wang, Panagiotis Mistriotis, Selma A. Serra, John D. Lewis, Miguel A. Valverde, Stuart S. Martin, Sean X. Sun, Konstantinos Konstantopoulos
Nature Communications  ·  17 Oct 2022
cell migrationmetastasisSWELL1polarized NHE1
Source
Migration and 3D Traction Force Measurements inside Compliant Microchannels
Alexandros Afthinos, Kaustav Bera, Junjie Chen, Altug Ozcelikkale, Alice Amitrano, Mohammad Ikbal Choudhury, Randy Huang, Pavlos Pachidis, Panagiotis Mistriotis, Yun Chen, Konstantinos Konstantopoulos
Nano Letters  ·  15 Sep 2022
cell migrationstiffness3D traction force
Integrating pharmacogenomics data-driven prediction with bulk and single-cell RNAseq to demonstrate the efficacy of an NAMPT inhibitor against aggressive, taxane-resistant, and stem-like cells in lethal prostate cancer
Suman Mazumder, Taraswi Mitra Ghosh, Ujjal K. Mukherjee, Sayak Chakravarti, Farshad Amiri, Farnaz Hemmati, Panagiotis Mistriotis, Isra Elhussin, Ahmad-bin Salam, Windy Dean-Colomb, Feng Li, Clayton Yates, Robert D. Arnold, Amit K. Mitra
Cold Spring Harbor Laboratory  ·  22 Jul 2022
pharmacogenomicssingle-cell RNAseqNAMPT inhibitorprostate cancer
Kidney epithelial cells are active mechano-biological fluid pumps
Mohammad Ikbal Choudhury, Yizeng Li, Panagiotis Mistriotis, Ana Carina N. Vasconcelos, Eryn E. Dixon, Jing Yang, Morgan Benson, Debonil Maity, Rebecca Walker, Leigha Martin, Fatima Koroma, Feng Qian, Konstantinos Konstantopoulos, Owen M. Woodward, Sean X. Sun
Nature Communications  ·  28 Apr 2022
kidneymorphogenesistissues

2021

The fluid shear stress sensor TRPM7 regulates tumor cell intravasation
Christopher L. Yankaskas, Kaustav Bera, Konstantin Stoletov, Selma A. Serra, Julia Carrillo-Garcia, Soontorn Tuntithavornwat, Panagiotis Mistriotis, John D. Lewis, Miguel A. Valverde, Konstantinos Konstantopoulos
Science Advances  ·  09 Jul 2021
fluid shear stressTRPM7intravasation
Abstract 1354: Deciphering the functional basis of synergy between taxanes and TAK715: A novel repurposed drug candidate in treatment-refractory aggressive prostate cancer
Sayak Chakravarti, Suman Mazumder, Farnaz Hemmati, Farshad Amiri, Taraswi Mitra Ghosh, Ujjal Kumar Mukherjee, Panagiotis Mistriotis, Timothy Moore, Robert Arnold, Clayton Yates, Amit Kumar Mitra
Cancer Research  ·  01 Jul 2021
taxanesTAK715prostate cancer
A Procarcinogenic Colon Microbe Promotes Breast Tumorigenesis and Metastatic Progression and Concomitantly Activates Notch and β-Catenin Axes
Sheetal Parida, Shaoguang Wu, Sumit Siddharth, Guannan Wang, Nethaji Muniraj, Arumugam Nagalingam, Christina Hum, Panagiotis Mistriotis, Haiping Hao, C. Conover Talbot, Konstantinos Konstantopoulos, Kathleen L. Gabrielson, Cynthia L. Sears, Dipali Sharma
Cancer Discovery  ·  06 Jan 2021
procarcinogenic microbebreast tumorigenesismetastasis

2020

Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma
Rajappa S. Kenchappa, Panagiotis Mistriotis, Emily Wisniewski, Santanu Bhattacharya, Tanmay Kulkarni, Rita West, Amanda Luu, Meghan Conlon, Ernest Heimsath, James F. Crish, Hannah S. Picariello, Athanassios Dovas, Natanael Zarco, Montserrat Lara-Velazquez, Alfredo Quiñones-Hinojosa, John A. Hammer, Debrabrata Mukhopadhyay, Richard E. Cheney, Konstantinos Konstantopoulos, Peter Canoll, Steven S. Rosenfeld
iScience  ·  01 Dec 2020
myosin 10glioblastomametabolic signaling
Dorsoventral polarity directs cell responses to migration track geometries
Emily O. Wisniewski, Panagiotis Mistriotis, Kaustav Bera, Robert A. Law, Jitao Zhang, Milos Nikolic, Michael Weiger, Maria Parlani, Soontorn Tuntithavornwat, Alexandros Afthinos, Runchen Zhao, Denis Wirtz, Petr Kalab, Giuliano Scarcelli, Peter Friedl, Konstantinos Konstantopoulos
Science Advances  ·  31 Jul 2020
dorsoventral polaritycell migration
Abstract PR06: Bacteroides fragilis: A potential pathogen orchestrating EMT and stemness in breast epithelial cells via concomitant activation of Notch and βcatenin axes
Sheetal Parida, Shaoguang Wu, Nethaji Muniraj, Sumit Siddharth, Arumugam Nagaligam, Christina Hum, Panagiotis Mistriotis, Konstantinos Konstantopoulos, Cynthia Sears, Dipali Sharma
Cancer Research  ·  15 Apr 2020
breast epithelial cellsBacteroides fragilis

2019

Confinement hinders motility by inducing RhoA-mediated nuclear influx, volume expansion, and blebbing
Panagiotis Mistriotis, Emily O. Wisniewski, Kaustav Bera, Jeremy Keys, Yizeng Li, Soontorn Tuntithavornwat, Robert A. Law, Nicolas A. Perez-Gonzalez, Eda Erdogmus, Yuqi Zhang, Runchen Zhao, Sean X. Sun, Petr Kalab, Jan Lammerding, Konstantinos Konstantopoulos
Journal of Cell Biology  ·  05 Nov 2019
nuclear influxconfinementRhoAmotility
Restoring extracellular matrix synthesis in senescent stem cells
Na Rong, Panagiotis Mistriotis, Xiaoyan Wang, Georgios Tseropoulos, Nika Rajabian, Yali Zhang, Jianmin Wang, Song Liu, Stelios T. Andreadis
The FASEB Journal  ·  09 Jul 2019
extracellular matrixsenescent stem cells
Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area
Runchen Zhao, Alexandros Afthinos, Tian Zhu, Panagiotis Mistriotis, Yizeng Li, Selma A. Serra, Yuqi Zhang, Christopher L. Yankaskas, Shuyu He, Miguel A. Valverde, Sean X. Sun, Konstantinos Konstantopoulos
Science Advances  ·  05 Jul 2019
TRPM7confinementhydraulic pressure
A Direct Podocalyxin–Dynamin-2 Interaction Regulates Cytoskeletal Dynamics to Promote Migration and Metastasis in Pancreatic Cancer Cells
Bin Sheng Wong, Daniel J. Shea, Panagiotis Mistriotis, Soontorn Tuntithavornwat, Robert A. Law, Jake M. Bieber, Lei Zheng, Konstantinos Konstantopoulos
Cancer Research  ·  01 Jun 2019
pancreatic cancer cellsmigrationmetastasis
A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens
Christopher L. Yankaskas, Keyata N. Thompson, Colin D. Paul, Michele I. Vitolo, Panagiotis Mistriotis, Ankit Mahendra, Vivek K. Bajpai, Daniel J. Shea, Kristen M. Manto, Andreas C. Chai, Navin Varadarajan, Aikaterini Kontrogianni-Konstantopoulos, Stuart S. Martin, Konstantinos Konstantopoulos
Nature Biomedical Engineering  ·  06 May 2019
microfluidic assaybreast cancermetastasis

2018

Exposing Cell-Itary Confinement: Understanding the Mechanisms of Confined Single Cell Migration
Bin Sheng Wong, Panagiotis Mistriotis, Konstantinos Konstantopoulos
Advances in Experimental Medicine and Biology  ·  01 Jan 2018
osmotic enginecell blebbingamoeboid migrationconfinement

2017

Vascular aging: Molecular mechanisms and potential treatments for vascular rejuvenation
Panagiotis Mistriotis, Stelios T. Andreadis
Ageing Research Reviews  ·  01 Aug 2017
vscular agingvascular rejuvenation
Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3
S Sengupta, A Nagalingam, N Muniraj, M Y Bonner, P Mistriotis, A Afthinos, P Kuppusamy, D Lanoue, S Cho, P Korangath, M Shriver, A Begum, V F Merino, C-Y Huang, J L Arbiser, W Matsui, B Győrffy, K Konstantopoulos, S Sukumar, P A Marignani, N K Saxena, D Sharma
Oncogene  ·  05 Jun 2017
LKB1breast cancerStat3 inhibition
NANOG Restores Contractility of Mesenchymal Stem Cell-Based Senescent Microtissues
Aref Shahini, Panagiotis Mistriotis, Mohammadnabi Asmani, Ruogang Zhao, Stelios T. Andreadis
Tissue Engineering Part A  ·  01 Jun 2017
nanogcontractilitymesenchymal stem cells

2016

Cancer cell motility: lessons from migration in confined spaces
Colin D. Paul, Panagiotis Mistriotis, Konstantinos Konstantopoulos
Nature Reviews Cancer  ·  02 Dec 2016
cell motilitymigationcancerconfined spaces
NANOG Reverses the Myogenic Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression
Panagiotis Mistriotis, Vivek K. Bajpai, Xiaoyan Wang, Na Rong, Aref Shahini, Mohammadnabi Asmani, Mao-Shih Liang, Jianmin Wang, Pedro Lei, Song Liu, Ruogang Zhao, Stelios T. Andreadis
Stem Cells  ·  11 Jul 2016
nanogmyogenic differentiationsenescent stem cells

2014

Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation
Roshan M Padmashali, Panagiotis Mistriotis, Mao-shih Liang, Stelios T Andreadis
Molecular Therapy  ·  01 Nov 2014
lentiviral arraysdifferentiationdynamic monitoring

2013

Poly(ethylene glycol)-block-cationic polylactide nanocomplexes of differing charge density for gene delivery
Chih-Kuang Chen, Charles H. Jones, Panagiotis Mistriotis, Yun Yu, Xiaoni Ma, Anitha Ravikrishnan, Ming Jiang, Stelios T. Andreadis, Blaine A. Pfeifer, Chong Cheng
Biomaterials  ·  01 Dec 2013
cationic polymernanocomplexgene delivery
Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine
Panagiotis Mistriotis, Stelios T. Andreadis
Tissue Engineering Part B: Reviews  ·  01 Aug 2013
hair folliclemultipotent stem cellsregenerative medicine
Hair Follicle: A Novel Source of Stem Cells for Cell and Gene Therapy
Panagiotis Mistriotis, Stelios T. Andreadis
Emerging Trends in Cell and Gene Therapy  ·  01 Jan 2013
hair folliclestem cellsgene therapy

2012

Nanog Reverses the Effects of Organismal Aging on Mesenchymal Stem Cell Proliferation and Myogenic Differentiation Potential
Juhee Han, Panagiotis Mistriotis, Pedro Lei, Dan Wang, Song Liu, Stelios T. Andreadis
STEM CELLS  ·  27 Nov 2012
NanogOrganismal Agingmesenchymal stem cells
Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates
Vivek K. Bajpai, Panagiotis Mistriotis, Yuin-Han Loh, George Q. Daley, Stelios T. Andreadis
Cardiovascular Research  ·  31 Aug 2012
smooth muscle cellshuman induced pluripotent stem cells
Clonal multipotency and effect of long-term in vitro expansion on differentiation potential of human hair follicle derived mesenchymal stem cells
Vivek K. Bajpai, Panagiotis Mistriotis, Stelios T. Andreadis
Stem Cell Research  ·  01 Jan 2012
clonal multipotencyhuman hair folliclemesenchymal stem cells

2008

Biotransformations of natural compounds: Structural and functional diversity of novel derivatives
Epameinondas Xanthakis, Panos Mistriotis, Haralampos Stamatis, Sophia Magkouta, Heleni Loutrari, Charis Roussos, Fragiskos Kolisis
Journal of Biotechnology  ·  01 Oct 2008
biotransformationsnatural compoundsderivatives

2007

Manganese species from human serum, cerebrospinal fluid analyzed by size exclusion chromatography-, capillary electrophoresis coupled to inductively coupled plasma mass spectrometry
Bernhard Michalke, Achim Berthele, Panos Mistriotis, Maria Ochsenkühn-Petropoulou, Stefan Halbach
Journal of Trace Elements in Medicine and Biology  ·  01 Dec 2007
human cerebrospinal fluidcapillary electrophoresismanganese species
Manganese speciation in human cerebrospinal fluid using CZE coupled to inductively coupled plasma MS
Bernhard Michalke, Achim Berthele, Panos Mistriotis, Maria Ochsenkühn-Petropoulou, Stefan Halbach
ELECTROPHORESIS  ·  01 May 2007
human cerebrospinal fluidcoupled plasmamanganese species
Size characterization of manganese species from human serum and cerebrospinal fluid using size exclusion chromatography coupled to inductively coupled plasma mass spectrometry
Bernhard Michalke, Stefan Halbach, Achim Berthele, Panos Mistritiotis, Maria Ochsenkühn-Petropoulou
J. Anal. At. Spectrom.  ·  01 Jan 2007
cerebrospinal fluidplasma mass spectrometrymanganese species

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